Despite James' prolific scoring, it wasn't enough to prevent the Lakers from losing by 116 points to 104.
Minnesota's Gary Trent Jr. equalled a record set by legendary player Ray Allen when he scored 9 three-pointers in the game.
The Timberwolves will have home-court advantage at the Target Center in Minneapolis when the teams meet again tomorrow evening at 9.30 p.m. Slovenian time.
